Creating a new generation of small molecule protease inhibitors

Key Publications

Journals

Simao F, Ustunkaya T, Clermont AC and Feener EP Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke. Blood. 2017.
PMID:28130211

Clermont A, Murugesan N, Zhou Q, Kita T, Robson PA, Rushbrooke LJ, Evans DM, Aiello LP, Feener EP. Plasma Kallikrein Mediates Vascular Endothelial Growth Factor-Induced Retinal Dysfunction and Thickening. Invest Ophthalmol Vis Sci. 2016;57:2390-9.
PMID:27138737

Kita T, Clermont AC, Murugesan N, Zhou Q, Fujisawa K, Ishibashi T, Aiello LP, Feener EP. Plasma Kallikrein-Kinin System as a VEGF-Independent Mediator of Diabetic Macular Edema. Diabetes. 2015;64:3588-99.
PMID:25979073

Liu J, Clermont AC, Gao BB, Feener EP. Intraocular hemorrhage causes retinal vascular dysfunction via plasma kallikrein. Invest Ophthalmol Vis Sci. 2013;54:1086-1094.
PMID:23299478

Clermont A, Chilcote TJ, Kita T, Liu J, Riva P, Sinha S and Feener EP. Plasma kallikrein mediates retinal vascular dysfunction and induces retinal thickening in diabetic rats. Diabetes. 2011;60(5):1590-8.
PMID:21444925

Liu J, Gao B-B, Clermont AC, Blair P, Chilcote TJ, Sinha S, Flaumenhaft R and Feener EP. Hyperglycemia induced cerebral hematoma expansion is mediated by plasma kallikrein. Nature Medicine. 2011;17:206-10.
PMID:21258336

Feener EP. Plasma kallikrein and diabetic macular edema. Curr. Diab. Rep. 2010 Aug;10(4):270-5.
PMID:20535647

Phipps JA, Clermont AC, Sinha S, Chilcote TJ, Bursell S-E and Feener EP. Plasma kallikrein mediates angiotensin AT1 receptor stimulated retinal vascular permeability. Hypertension 2009;53:175-81.
PMID:19124682

Phipps JA and Feener EP. The kallikrein-kinin system in diabetic retinopathy: Lessons for the kidney. Kidney Int., 2008;73(10):1114-9.
PMID:18272958

Mac

Gao BB, Clermont A, Rook S, Fonda SJ, Srinivasan VJ, Wojtkowski M, Fujimoto JG, Avery RL, Arrigg PG, Bursell SE, Aiello LP and Feener EP. Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. Nature Medicine. 2007;13:181-8.
PMID:17259996