Creating a new generation of small molecule protease inhibitors

Overview

KalVista is a pharmaceutical company focused on the discovery, development and commercialization of small molecule protease inhibitors as new treatments for diseases with significant unmet need.

Medic-patient meeting

Our initial focus is on inhibitors of plasma kallikrein, which is an important component of the body’s inflammatory response and which, in excess, can lead to increased vascular permeability, edema and inflammation. We have developed a proprietary portfolio of novel, small molecule plasma kallikrein inhibitors initially targeting hereditary angioedema (HAE) and diabetic macular edema (DME).

The strategy is to develop a portfolio of oral molecules and evaluate multiple candidates in the clinic to provide a best-in-class therapy for HAE patients. As part of this strategy, we will select molecules whose properties can support multiple therapies for HAE patients, such as for prophylactic as well as acute treatment.

Research and Development

Our first candidate of this planned portfolio of programs is currently in a first-in-human study and additional program candidates are in preclinical development.

The most advanced program, KVD001, an intravitreally administered plasma kallikrein inhibitor, has successfully completed its first-in-human study in patients with DME and a Phase 2 trial is being planned. In October 2017, we entered into a collaboration agreement with Merck for KVD001 as well as future oral DME compounds based upon plasma kallikrein inhibition.

We have an R&D team with an established track record in the pharmaceutical development of small molecule protease inhibitors, world-leading expertise in the role of plasma kallikrein in disease, and a management team with the capability to bring small molecules through the clinic to commercialization.

Our offices are in Cambridge, MA, USA and Salisbury, UK.