KalVista Pharmaceuticals is a company focused on the discovery, development and commercialization of oral, small molecule protease inhibitors as new treatments for diseases with significant unmet need.
We have developed a proprietary portfolio of novel, small molecule plasma kallikrein inhibitors initially targeting hereditary angioedema (HAE) and diabetic macular edema (DME).
Sebetralstat is being developed as an on-demand therapy for acute HAE attacks, with the ongoing Phase 3 KONFIDENT clinical trial. KVD824 is in development for prophylactic treatment of HAE with the Phase 2 KOMPLETE clinical trial underway. Our oral Factor XIIa inhibitor program represents a new generation of therapies that may further improve the treatment of HAE for patients. In DME, an intravitreally administered plasma kallikrein inhibitor called KVD001, completed a Phase 2 clinical trial.