About KalVista


KalVista Pharmaceuticals is a company focused on the discovery, development and commercialization of oral, small molecule protease inhibitors as new treatments for diseases with significant unmet need.

We have developed a proprietary portfolio of novel, small molecule plasma kallikrein inhibitors initially targeting hereditary angioedema (HAE) and diabetic macular edema (DME).

Sebetralstat is being developed as an on-demand therapy for acute HAE attacks, with the ongoing Phase 3 KONFIDENT clinical trial. Our oral Factor XIIa inhibitor program represents a new generation of therapies that may further improve the treatment of HAE for patients. In DME, an intravitreally administered plasma kallikrein inhibitor called KVD001, completed a Phase 2 clinical trial.


We have an R&D team with an established track record in the pharmaceutical development of small molecule protease inhibitors, world-leading expertise in the role of plasma kallikrein in disease, and a management team with the capability to bring small molecules through the clinic to commercialization.

Our offices and labs are in Cambridge, MA, Salisbury, UK and Salt Lake City, UT.