HAE Information for Healthcare Professionals

What’s the best way to help your patients with hereditary angioedema (HAE)?

Give them the best care and treatment available.

We are KalVista Pharmaceuticals, Inc.; a research-based drug company with offices in the US and UK.

We are dedicated to developing small molecular protease inhibitors that we believe can help patients with diseases such as HAE. We have created a portfolio of oral plasma kallikrein inhibitors and advanced multiple candidates into clinical trials for HAE.

Our goal is to create oral HAE therapies to give patients more and better options for how they treat their disease. Our most advanced candidate is sebetralstat, a potential oral therapy being developed for on-demand treatment of HAE. In February 2021 we reported positive results for sebetralstat in a Phase 2 clinical trial that demonstrated statistically and clinically significant responses across primary and secondary endpoints as an oral on-demand treatment for HAE attacks. On the basis of that trial, in March 2022 we announced the initiation of the sebetralstat Phase 3 KONFIDENT trial, evaluating the safety and efficacy of sebetralstat as a potential oral, on-demand therapy for HAE attacks. 

Understanding HAE

A rare but potentially life-threatening disease, HAE is most frequently caused by a genetic disorder where the protein C1-inhibitor esterase is inadequately synthesized or dysfunctional. 

C1-inhibitor is a critical mediator of inflammation. With inadequate levels or malfunctioning C1-inhibitor, excess plasma kallikrein can become activated, leading the body to produce the vasopeptide bradykinin in excessive amounts, which in turn leads to increased vascular permeability and sudden onset of angioedema. 

Angioedema attacks can occur in the limbs, face, gastrointestinal tract and/or airways. Laryngeal episodes can happen to any patient and are potentially life-threatening.

Related Content