What to expect
Inflammation in the body is often linked to stress or physical activity, but not always. C1- inhibitor deficiency can also contribute to inflammation. That helps explain why some HAE attacks seem to occur spontaneously, with no apparent trigger.
HAE attacks are typically prevented or treated by replacing the missing C1-inhibitor protein or by other therapies that block the activity of plasma kallikrein or bradykinin. All the currently approved HAE therapies are delivered by injection.
How and where to get treatment for HAE
Attacks can typically be prevented or treated by replacing the missing protein through regular injections or by using other therapies that block the pathway that leads to the sudden swelling attacks. Because all the current therapies are injected or infused (given intravenously), they are less convenient to use and sometimes require additional assistance. KalVista is developing an oral medication that would be easier for patients to take in the early stages of an attack, which we believe could shorten the duration and severity of the swelling.
Resources for those living with HAE
Access information specific to you and your condition.