Positive Phase 2 Data for Oral KVD900 in Hereditary Angioedema (HAE)
Reduced use of rescue treatment for HAE attack
Mild to moderate HAE attacks treated with Sebetralstat significantly reduced use of rescue (p=0.001), with 15% of Sebetralstat treated attacks rescued compared to 30% on placebo at 12 hours.
Reduced time to symptom relief on PGI-C scale
Sebetralstat significantly reduced time to onset of symptom relief after HAE attacks on a Patient Global Impression of Change scale (PGI-C), with median time of 1.6 hours with Sebetralstat vs. 9 hours for with placebo (p=<0.0001).
Sustained cumulative symptom relief as assessed by VAS
Cumulative symptom relief (defined as 50% reduction in composite VAS score for three consecutive time points) was maintained at 24 hours (p=0.0005) vs. placebo.
Sebetralstat is an investigational product candidate currently in clinical development as an oral on-demand therapy for HAE attacks.