Creating a new generation of small molecule protease inhibitors for HAE and DME

Mild to moderate HAE attacks treated with Sebetralstat significantly reduced use of rescue (p=0.001), with 15% of Sebetralstat treated attacks rescued compared to 30% on placebo at 12 hours.

Sebetralstat significantly reduced time to onset of symptom relief after HAE attacks on a Patient Global Impression of Change scale (PGI-C), with median time of 1.6 hours with Sebetralstat vs. 9 hours for with placebo (p=<0.0001).

Cumulative symptom relief (defined as 50% reduction in composite VAS score for three consecutive time points) was maintained at 24 hours (p=0.0005) vs. placebo.