Novel Oral Small Molecule FXIIa Inhibitor Blocks Contact System Activation In Vivo

Allen C Clermont, Daniel Lee, Nivetha Murugesan, Hannah J Edwards, Stephen J Pethen, Edward J Duckworth, Sally L HamptonĀ and Edward P Feener

EAACI 2022

Oral factor XIIa inhibition blocks angiotensin converting enzyme inhibitor induced angioedema in mouse

Clermont AC, Murugesan N, Feener EP

KININ 2022

Oral FXIIa inhibitor KV998086 suppresses FXII zymogen mediated kallikrein kinin system activation

Murugesan N, Lee DK, Duckworth EJ, Smith SA, Clermont AC, Hampton SL, Feener EP

KININ 2022