Publications

KVD900 protects high molecular weight kininogen (HK) from ex vivo plasma kallikrein- mediated cleavage in plasma from patients with hereditary angioedema (HAE): Results from a semi-automated capillary-based immunoassay.
Feener EP, Murugesan N, Robson PA, Li L, Rushbrooke LJ, Thoonen R, De Donatis GM, Riedl M, Zuraw B and Hampton SL.
EAACI 2018

A novel oral plasma kallikrein (PKal) inhibitor KV123833 blocks VEGF-mediated retinal vascular hyperpermeability in a murine model of retinal edema (#3464).
Murugesan N, Clermont AC, Rushbrooke LJ, Robson PA, Thoonen R, Pethen SJ, Hampton SL and Feener EP. 
ARVO 2018

Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke.
Simao F, Ustunkaya T, Clermont AC and Feener EP. 
Blood. 2017.
PMID:28130211

Plasma Kallikrein Mediates Vascular Endothelial Growth Factor-Induced Retinal Dysfunction and Thickening.
Clermont A, Murugesan N, Zhou Q, Kita T, Robson PA, Rushbrooke LJ, Evans DM, Aiello LP, Feener EP.
Invest Ophthalmol Vis Sci. 2016; 57:2390-9.
PMID:27138737

Plasma Kallikrein-Kinin System as a VEGF-Independent Mediator of Diabetic Macular Edema.
Kita T, Clermont AC, Murugesan N, Zhou Q, Fujisawa K, Ishibashi T, Aiello LP, Feener EP.
Diabetes. 2015; 64:3588-99.
PMID:25979073

Intraocular hemorrhage causes retinal vascular dysfunction via plasma kallikrein.
Liu J, Clermont AC, Gao BB, Feener EP.
Invest Ophthalmol Vis Sci. 2013;54:1086-1094.
PMID:23299478

Plasma kallikrein mediates retinal vascular dysfunction and induces retinal thickening in diabetic rats.
Clermont A, Chilcote TJ, Kita T, Liu J, Riva P, Sinha S and Feener EP.
Diabetes. 2011;60(5):1590-8.
PMID:21444925

Hyperglycemia induced cerebral hematoma expansion is mediated by plasma kallikrein.
Liu J, Gao B-B, Clermont AC, Blair P, Chilcote TJ, Sinha S, Flaumenhaft R and Feener EP.
Nature Medicine. 2011;17:206-10.
PMID:21258336

Plasma kallikrein and diabetic macular edema.
Feener EP.
Curr. Diab. Rep. 2010 Aug; 10(4):270-5.
PMID:20535647

Plasma kallikrein mediates angiotensin AT1 receptor stimulated retinal vascular permeability.
Phipps JA, Clermont AC, Sinha S, Chilcote TJ, Bursell S-E and Feener EP.
Hypertension 2009; 53:175-81.
PMID:19124682

The kallikrein-kinin system in diabetic retinopathy: Lessons for the kidney.
Phipps JA and Feener EP.
Kidney Int., 2008;73(10):1114-9.
PMID:18272958

Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation.
Gao BB, Clermont A, Rook S, Fonda SJ, Srinivasan VJ, Wojtkowski M, Fujimoto JG, Avery RL, Arrigg PG, Bursell SE, Aiello LP and Feener EP.
Nature Medicine. 2007;13:181-8.
PMID:17259996

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