Publications Archive - KalVista Pharmaceuticals

Long-term Safety and Effectiveness of Sebetralstat for On-demand Treatment of HAE in Japan

Naoko Inomata, Atsushi Fukunaga, Daisuke Honda, Kazumasa Ohmura, Yuko Watanabe, Isao Ohsawa, Ya-Hsiu Chuang, Michael Smith, Matthew Iverson, Paul Audhya, Henriette Farkas, Michihiro Hide

the Japanese Society of Allergology Congress; October 24-26, 2025; Tokyo, Japan

Barriers to Timely On-demand Treatment of Hereditary Angioedema Attacks in Japan: A Patient Survey

Daisuke Honda, Sherry Danese, Julie Ulloa, Shigeru Yoshida, Vibha Desai, Paolo Bajcic, Paul Audhya

the Japanese Society of Allergology Congress; October 24-26, 2025; Tokyo, Japan

Impact of Delayed Treatment of Hereditary Angioedema Attacks: Insights from Patient Surveys from Europe

Paola Triggianese, Alexis Bocquet, Thomas Buttgereit, Tariq El-Shanawany, Tomaz Garcez, Padmalal Gurugama, Rashmi Jain, Sorena Kiani-Alikhan, Markus Magerl, Inmaculada Martinez-Saguer, Sinisa Savic, Patrick Yong, Andrea Zanichelli, Paolo Bajcic, Julie Ulloa, Sherry Danese, Paul K. Audhya, Mauro Cancian

2025 HAEi Regional Conference EMEA; October 10-12, 2025; Rome, Italy

Sebetralstat for On-demand Treatment of Hereditary Angioedema Attacks in European Participants: Interim Analysis from KONFIDENT-S

Mauro Cancian, Emel Aygören-Pürsün, Laurence Bouillet, Teresa Caballero, Danny M. Cohn, Henriette Farkas, Vesna Grivcheva-Panovska, Mar Guilarte, Sorena Kiani-Alikhan, Tamar Kinaciyan, Damia Leguevaques, Markus Magerl, Inmaculada Martinez-Saguer, Sinisa Savic, Maria Staevska, Petra Staubach, Marcin Stobiecki, Anna Valerieva, Patrick F. K. Yong, James Hao, Michael D. Smith, Christopher M. Yea, Paul K. Audhya, Andrea Zanichelli

2025 HAEi Regional Conference EMEA; October 10-12, 2025; Rome, Italy

Barriers to Timely On-Demand Treatment of Hereditary Angioedema Attacks in German Patients

Thomas Buttgereit, Markus Magerl, Sherry Danese, Julie Ulloa, Paolo Bajcic, Paul Audhya, Inmaculada Martinez-Saguer

Deutscher Allergie Kongress; October 2-4, 2025; Düsseldorf, Germany

Effectiveness of Sebetralstat for the On-demand Treatment of Mucosal Hereditary Angioedema Attacks: Interim Analysis from KONFIDENT-S

Emel Aygören-Pürsün, Inmaculada Martinez-Saguer, Jonathan Bernstein, Danny Cohn, Vesna Grivcheva-Panovska, William Lumry, Marc Riedl, Andrea Zanichelli, Laurence Bouillet, Ya-Hsiu Chuang, Michael Smith, Christopher Yea, Paul K. Audhya, Henriette Farkas, Petra Staubach, Markus Magerl

Deutscher Allergie Kongress; October 2-4, 2025; Düsseldorf, Germany

Impact of Oral Sebetralstat on Anxiety Associated with Hereditary Angioedema Attacks in the Phase 3 KONFIDENT Trial

Emel Aygören-Pürsün, Jonathan Bernstein, Timothy Craig, Paula Busse, Teresa Caballero, Danny Cohn, Mar Guilarte, Henriette Farkas, Douglas Jones, Sorena Kiani-Alikhan, Michael Manning, Marcus Maurer, Marc A. Riedl, Sinisa Savic, H. James Wedner, Patrick Yong, Andrea Zanichelli, Erik Hansen, James Hao, Michael Smith, Christopher Yea, Paul Audhya, William Lumry

Deutscher Allergie Kongress; October 2-4, 2025; Düsseldorf, Germany

Sebetralstat for On-demand Treatment of Hereditary Angioedema Attacks in European Participants: Interim Analysis from KONFIDENT-S

Inmaculada Martinez-Saguer, Petra Staubach, Teresa Caballero, Mar Guilarte, Ramon Lleonart Bellfill, James Hao, Michael Smith, Paul Audhya, Markus Magerl, Emel Aygören-Pürsün

Deutscher Allergie Kongress; October 2-4, 2025; Düsseldorf, Germany

Sebetralstat for Treatment of HAE Attacks in Patients Receiving Berotralstat: Interim Analysis from the KONFIDENT-S Open-label Study

Markus Magerl, Inmaculada Martinez-Saguer, Michael Manning, Marc Riedl, Raffi Tachdijan, Henry Li, James Wedner, Daniel Soteres, James Hao, Michael Smith, Paul Audhya, Tamar Kinaciyan, Petra Staubach-Renz, Emel Aygören-Pürsün

Deutscher Allergie Kongress; October 2-4, 2025; Düsseldorf, Germany

Time to End of Progression of Hereditary Angioedema Attacks Treated with Sebetralstat

Markus Magerl, Inmaculada Martinez-Saguer, William Lumry, John Anderson, Jonathon Bernstein, Mauro Cancian, Danny Cohn, Henriette Farkas, Henry Li, James Hao, Michael Smith, Paul Audhya, Petra Staubach-Renz, Emel Aygören-Pürsün

Deutscher Allergie Kongress; October 2-4, 2025; Düsseldorf, Germany

Sebetralstat for On-demand Treatment of Hereditary Angioedema Attacks in European Participants: Interim Analysis from KONFIDENT-S

Mar Guilarte, Ramon Lleonart Bellfill, James Hao, Michael Smith, Paul Audhya, Teresa Caballero

The 35th National Congress of the Spanish Society of Allergology and Clinical Immunology 2025; October 1-4, 2025; Granada, Spain

Sebetralstat for Treatment of HAE Attacks in Patients Receiving Berotralstat, Lanadelumab, or C1 Inhibitor for Long-term Prophylaxis: Interim Analysis from KONFIDENT-S

William Lumry, Emel Aygören-Pürsün, Jonathan Bernstein, Paula Busse, Mauro Cancian, Danny Cohn, Timothy Craig, Henriette Farkas, Sorena Kiani-Alikhan, Tamar Kinaciyan, H. Henry Li, Michael Manning, Jason Raasch, Marc Riedl, Daniel Soteres, Raffi Tachdjian, H. James Wedner, James Hao, Michael Smith, Paul Audhya, Andrea Zanichelli

Consortium of Independent Immunology Clinics (CIIC) Fall Conference; September 26-28, 2025; Tampa, Florida

On-demand Treatment of Hereditary Angioedema Attacks with Sebetralstat in Adolescents: Interim Analysis from KONFIDENT-S

Inmaculada Martinez-Saguer, Rand Arnaout, Danny Cohn, Henriette Farkas, Tamar Kinaciyan, Jonathan Peter, Fotios Psarros, Petra Staubach, Andrea Zanichelli, James Hao, Michael Smith, Paul Audhya, Markus Magerl, Emel Aygören-Pürsün

Annual Congress for Pediatric and Adolescent Medicine (DGKJ); September 24-27, 2025; Leipzig, Germany

The Kallikrein Kinin System Alters Neuroretinal and Visual Responses in Mice

Allen Clermont, Nivetha Murugesan, Cheng-Mao Lin, David Antonetti, Lloyd Aiello, Edward Feener

Exp Eye Res. 2025 Sep:258:110484.

Impact of Hereditary Angioedema Attacks on Health-related Quality of Life and Work Productivity

Maeve O'Connor, Paula Busse, Timothy Craig, Cristine Radojicic, James Wedner, Sherry Danese, Julie Ulloa, Vibha Desai, Tomas Andriotti, Paul Audhya, Sandra Christiansen

World Allergy Organ J. 2025 Jul 28;18(8):101083

Delays and Barriers Related to the Treatment of Hereditary Angioedema Attacks in Italy

Francesco Arcoleo, Francesco Giardino, Stefania Nicola, Riccardo Senter, Paola Triggianese, Sherry Danese, Julie Ulloa, Vibha Desai, Joao Frade, Paul Audhya, Andrea Zanichelli on behalf of the ITACA Group

Allergy. 2025 Jul 16. Online ahead of print.

Effectiveness of Sebetralstat for the On-demand Treatment of Mucosal Hereditary Angioedema Attacks: Interim Analysis from KONFIDENT-S

Marc Riedl, Jonathan Bernstein, Emel Aygören-Pürsün, Vesna Grivcheva-Panovska, Inmaculada Martinez-Saguer, Danny Cohn, William Lumry, Andrea Zanichelli, Laurence Bouillet, Ya-Hsiu Chuang, Michael Smith, Christopher Yea, Paul Audhya, Henriette Farkas

Presented at the 2025 US HAEA National Summit; July 10-13, 2025; Baltimore, Maryland

Impact of Injectable HAE On-demand Treatments on Health-related Quality of Life: A Patient and Caregiver Interview Study

Timothy Craig, Aleena Banerji, Paula Busse, Sorena Kiani-Alikhan, Patrick Yong, Rebekah Hall, Siu Hing Lo, Caleb Dixon, Paul Audhya, Alice Wang, Tomaz Garcez

Presented at the 2025 US HAEA National Summit; July 10-13, 2025; Baltimore, Maryland

Impact of Oral Sebetralstat on Anxiety Associated with Hereditary Angioedema Attacks in the Phase 3 KONFIDENT Trial

Timothy Craig, Emel Aygören-Pürsün, Jonathan Bernstein, Paula Busse, Teresa Caballero, Danny Cohn, Mar Guilarte, Henriette Farkas, Douglas Jones, Sorena Kiani-Alikhan, Michael Manning, Marcus Maurer, Marc Riedl, Sinisa Savic, H. James Wedner, Patrick Yong, Andrea Zanichelli, Erik Hansen, James Hao, Michael Smith, Christopher Yea, Paul Audhya, William Lumry

Presented at the 2025 US HAEA National Summit; July 10-13, 2025; Baltimore, Maryland

Long-Term Prophylaxis Compliance for Hereditary Angioedema and the Impact on On-demand Treatment Claims

Maeve O'Connor, Daniel Soteres, Raffi Tachdjian, Chirag Maheshwari, Alice Wang, Paul Audhya, Timothy Craig

Presented at the 2025 US HAEA National Summit; July 10-13, 2025; Baltimore, Maryland

Survey Results from Italy, the US, UK, and France: Anxiety in Patients Using Injectable On-Demand Treatments for Hereditary Angioedema Attacks

Mauro Cancian, Alexis Bocquet, Paula Busse, Timothy Craig, Tariq El-Shanawany, Tomaz Garcez, Padmalal Gurugama, Rashmi Jain, Sorena Kiani-Alikhan, Maeve O’Connor, Cristine Radojicic, Sinisa Savic, Paola Triggianese, H. James Wedner, Patrick Yong, Andrea Zanichelli, Julie Ulloa, Sherry Danese, Paul Audhya, Sandra Christiansen

Presented at the 2025 US HAEA National Summit; July 10-13, 2025; Baltimore, Maryland

Closing Gaps in HAE Management: Understanding What Control Means for Your Patients with HAE

Douglas Jones, Stephen Betschel, Thomas Buttgereit, Sinisa Savic

Eur Med J Allergy Immunol. 2025 July; 10.1

Adherence to Long-Term Prophylaxis for Hereditary Angioedema and the Impact on On-demand Treatment Claims in the US

Daniel F. Soteres, Raffi Tachdjian, Maeve O'Connor, Chirag Maheshwari, Alice Wang, Paul K. Audhya, Timothy Craig

Presented at the European Academy of Allergy and Clinical Immunology (EAACI); June 13-16, 2025; Glasgow, United Kingdom

Anxiety Associated with Parenteral On-Demand Treatment for Hereditary Angioedema Attacks in Patients from Italy

Mauro Cancian, Andrea Zanichelli, Pietro Accardo, Francesco Arcoleo, Donatella Bignardi, Caterina Colangelo, Francesco Giardino, Antonio Gidaro, Marica Giliberti, Maria Domenica Guarino, Paola Lucia Minciullo, Stefania Nicola, Francesca Perego, Riccardo Senter, Giuseppe Spadaro, Paola Triggianese, Massimo Triggiani, Sherry Danese, Julie Ulloa, Vibha Desai, Paul Audhya, Andrea Zanichelli

Presented at the European Academy of Allergy and Clinical Immunology (EAACI); June 13-16, 2025; Glasgow, United Kingdom

Impact of Delayed Treatment of Hereditary Angioedema Attacks: Insights from Patient Surveys Across France, the United Kingdom, and the United States

Alexis Bocquet, Paula J. Busse, Timothy Craig, Tariq El-Shanawany, Tomaz Garcez, Padmalal Gurugama, Rashmi Jain, Sorena Kiani-Alikhan, Maeve O’Connor, Cristine Radojicic, Sinisa Savic, H. James Wedner, Patrick F.K. Yong, Sherry Danese, Julie Ulloa, Vibha Desai, Paul K. Audhya, Sandra Christiansen

Presented at the European Academy of Allergy and Clinical Immunology (EAACI); June 13-16, 2025; Glasgow, United Kingdom

Potential for Sebetralstat to Address Pseudo-allergic Reaction Burden Secondary to Icatibant in HAE

Sally Hampton, Paul Audhya, Michael Smith, Christopher Yea

Presented at the European Academy of Allergy and Clinical Immunology (EAACI); June 13-16, 2025; Glasgow, United Kingdom

Psychological Burden Associated with Injectable HAE On-demand Treatments: A Patient and Caregiver Interview Study

Sorena Kiani-Alikhan, Aleena Banerji, Paula Busse, Timothy Craig, Patrick Yong, Rebekah Hall, Siu Hing Lo, Caleb Dixon, Paul Audhya, Alice Wang, Tomaz Garcez

Presented at the European Academy of Allergy and Clinical Immunology (EAACI); June 13-16, 2025; Glasgow, United Kingdom

Sebetralstat for Treatment of HAE Attacks in Patients Receiving Berotralstat, Lanadelumab, or C1 Inhibitor for Long-term Prophylaxis: Interim Analysis from KONFIDENT-S

Marc Riedl, Emel Aygören-Pursun, Jonathon Bernstein, Paula Busse, Mauro Cancian, Danny Cohn, Tim Craig, Henriette Farkas, Sorena Kiani, Tamar Kinaciyan, Henry Li, William Lumry, Michael Manning, Jason Raasch, Dan Soteres, Raffi Tachdjian, James Wedner, James Hao, Michael Smith, Paul Audhya, Andrea Zanichelli

Presented at the European Academy of Allergy and Clinical Immunology (EAACI); June 13-16, 2025; Glasgow, United Kingdom

Anxiety Associated with Hereditary Angioedema Attacks: Results from the Phase 3 KONFIDENT Trial of Oral Sebetralstat

Timothy Craig, Emel Aygören-Pürsün, Jonathan Bernstein, Paula Busse, Teresa Caballero, Danny Cohn, Mar Guilarte, Henriette Farkas, Douglas Jones, Sorena Kiani-Alikhan, Michael Manning, Marcus Maurer, Marc Riedl, Sinisa Savic, H. James Wedner, Patrick Yong, Andrea Zanichelli, Erik Hansen, James Hao, Michael Smith, Christopher Yea, Paul Audhya, William Lumry

Presented at 14th C1-Inhibitor Deficiency & Angioedema (C1-INH) Workshop; May 29 - June 1, 2025; Budapest, Hungary

Effectiveness of Sebetralstat for the On-demand Treatment of Mucosal Hereditary Angioedema Attacks: Interim Analysis from KONFIDENT-S

Jonathan Bernstein, Vesna Grivcheva-Panovska, Emel Aygören-Pürsün, Inmaculada Martinez-Saguer, Danny Cohn, William Lumry, Marc Riedl, Andrea Zanichelli, Laurence Bouillet, Ya-Hsiu Chuang, Michael Smith, Christopher Yea, Paul Audhya, Henriette Farkas

Presented at 14th C1-Inhibitor Deficiency & Angioedema (C1-INH) Workshop; May 29 - June 1, 2025; Budapest, Hungary

Impact of Injectable HAE On-demand Treatments on Health-related Quality of Life: A Patient and Caregiver Interview Study

Patrick Yong, Aleena Banerji, Paula Busse, Timothy Craig, Sorena Kiani-Alikhan, Rebekah Hall, Siu Hing Lo, Caleb Dixon, Paul Audhya, Alice Wang, Tomaz Garcez

Presented at 14th C1-Inhibitor Deficiency & Angioedema (C1-INH) Workshop; May 29 - June 1, 2025; Budapest, Hungary

In Their Own Words, Patient Perspectives on Time to Feeling in Control of an HAE Attack

Doug Jones, Anna Valerieva, Mar Guilarte, Neil Malloy, Sally van Kooten, Markus Heckmann, Markus Magerl

Presented at 14th C1-Inhibitor Deficiency & Angioedema (C1-INH) Workshop; May 29 - June 1, 2025; Budapest, Hungary

Survey Results from Italy, the US, UK, and France: Anxiety in Patients Using Injectable On-Demand Treatments for Hereditary Angioedema Attacks

Mauro Cancian, Alexis Bocquet, Paula Busse, Timothy Craig, Tariq El-Shanawany, Tomaz Garcez, Padmalal Gurugama, Rashmi Jain, Sorena Kiani-Alikhan, Maeve O’Connor, Cristine Radojicic, Sinisa Savic, Paola Triggianese, H. James Wedner, Patrick Yong, Andrea Zanichelli, Julie Ulloa, Sherry Danese, Paul K. Audhya, Sandra Christiansen

Presented at 14th C1-Inhibitor Deficiency & Angioedema (C1-INH) Workshop; May 29 - June 1, 2025; Budapest, Hungary

Time to End of Progression of Hereditary Angioedema Attacks Treated with Sebetralstat

William Lumry, John Anderson, Jonathan Bernstein, Mauro Cancian, Danny Cohn, Henriette Farkas, H. Henry Li, James Hao, Michael Smith, Paolo Bajcic, Paul K. Audhya, Markus Magerl

Presented at 14th C1-Inhibitor Deficiency & Angioedema (C1-INH) Workshop; May 29 - June 1, 2025; Budapest, Hungary

Effectiveness of Sebetralstat for Severe or Very Severe Hereditary Angioedema Attacks in KONFIDENT-S

Henry Li, William Lumry, Michael Manning, Marc Riedl, James Wedner, James Hao, Michael Smith, Paul Audhya, Jonathan Bernstein

Presented at the Eastern Allergy Conference (EAC); May 29 - June 1, 2025; Palm Beach, Florida

Long-Term Prophylaxis Compliance and Healthcare Resource Utilization in Hereditary Angioedema: A Claims Database Analysis

Raffi Tachdjian, Daniel Soteres, Maeve O'Connor, Chirag Maheshwari, Alice Wang, Paul Audhya, Timothy Craig

Presented at the Eastern Allergy Conference (EAC); May 29 - June 1, 2025; Palm Beach, Florida

On-demand Treatment of Hereditary Angioedema Attacks with Sebetralstat in Older Adults: Interim Analysis from KONFIDENT-S

Daniel Soteres, Alan Baptist, Jonathan Bernstein, Timothy Craig, William Lumry, James Hao, Michael Smith, Paolo Bajcic, Paul Audhya, Marc Riedl

Presented at the Eastern Allergy Conference (EAC); May 29 - June 1, 2025; Palm Beach, Florida

Time to End of Progression of Hereditary Angioedema Attacks Treated with Sebetralstat

Daniel Soteres, William Lumry, John Anderson, Jonathan Bernstein, Mauro Cancian, Danny Cohn, Henriette Farkas, Henry Li, James Hao, Michael Smith, Paolo Bajcic, Paul Audhya, Markus Magerl

Presented at the Eastern Allergy Conference (EAC); May 29 - June 1, 2025; Palm Beach, Florida

Effectiveness of Sebetralstat for the On-demand Treatment of Laryngeal Hereditary Angioedema Attacks: Interim Analysis from KONFIDENT-S

Naoko Inomata, Atsushi Fukunaga, Jonathan Bernstein, Emel Aygören-Pürsün, Vesna Grivcheva-Panovska, Inmaculada Martinez-Saguer, James Hao, Michael Smith, Paul Audhya, Henriette Farkas

Presented at the 124th Annual Meeting of the Japanese Dermatological Association (JDA); May 29 - June 1, 2025; Yokohama, Japan

Impact of Oral Sebetralstat on Anxiety Associated with Hereditary Angioedema Attacks

Yuko Watanabe, Michihiro Hide, Danny Cohn, Henriette Farkas, William Lumry, Marc Riedl, James Hao, Michael Smith, Paul Audhya, Emel Aygören-Pürsün

Presented at the 124th Annual Meeting of the Japanese Dermatological Association (JDA); May 29 - June 1, 2025; Yokohama, Japan

Pooled Sebetralstat Efficacy and Safety for On-demand Treatment of Hereditary Angioedema

Daisuke Honda, Jonathan Bernstein, Danny Cohn, Sorena Kiani-Alikhan, Marc Riedl, James Hao, Michael Smith, Paul Audhya, Emel Aygören-Pürsün, Michihiro Hide

Presented at the 124th Annual Meeting of the Japanese Dermatological Association (JDA); May 29 - June 1, 2025; Yokohama, Japan

Factors Contributing to Non-compliance with On-demand Treatment Guidelines in Hereditary Angioedema

Stephen Betschel, Jonny Peter, William Lumry, Hilary Longhurst, Constance Katelaris, Sally van Kooten, Markus Heckmann, Neil Malloy, Julie Ulloa, Sherry Danese, Markus Magerl

Allergy Asthma Clin Immunol. 2025 May 21;21(1):25.

On-demand Treatment of Hereditary Angioedema Attacks: Patient-reported Utilization, Barriers, and Outcomes

Sandra Christiansen, Maeve O’Connor, Timothy Craig, Cristine Radojicic, James Wedner, Sherry Danese, Julie Ulloa, Vibha Desai, Christopher Utter, Tomas Andriotti, Paul Audhya, Paula Busse

Ann Allergy Asthma Immunol. 2025 May;134(5):570-579.e4.

Global Frequency, Diagnosis, and Treatment of Hereditary Angioedema with Normal C1 Inhibitor

Markus Magerl, Marc Riedl, Luisa Karla Arruda, Andrea Bauer, Alejandro Berardi, Jonathan Bernstein, Laurence Bouillet, Matthew Buckland, Thomas Buttgereit, Danny Cohn, Timothy Craig, Roberta Criado, Aurélie Du-Thanh, Olivier Fain, Margarida Gonçalo, Jens Greve, Anete Sevciovic Grumach, Mar Guilarte, Constance Katelaris, Tamar Kinaciyan, Elena Latysheva, Ramon Lleonart, Oscar Calderón Llosa, Eli Mansour, Vesna Grivcheva-Panovska, Claudio Parisi, Nelson Augusto Rosario Filho, Amélia Spínola Santos, Petra Staubach, Anna Valerieva, Solange Oliveira Rodrigues Valle, Sherry Danese, Julie Ulloa, Paul Audhya, Marcus Maurer

J Allergy Cli Immunol Global. 2025 August; 4(3)100446. Online ahead of print.

Interplay of On-demand Trials for Hereditary Angioedema Attacks and Treatment Guidelines

Danny Cohn, Daniel Soteres, Timothy Craig, William Lumry, Markus Magerl, Marc Riedl, Paul Audhya, Marcus Maurer, Jonathan Bernstein

J Allergy Clin Immunol. 2025 Mar;155(3):726-739

Healthcare Utilization and Costs Among Hereditary Angioedema Patients Receiving Long-Term Prophylaxis: Results of a Claims Database Analysis

Raffi Tachdjian, Daniel Soteres, Maeve O'Connor, Chirag Maheshwari, Alice Wang, Paul Audhya, Timothy Craig

Presented at the Academy of Managed Care Pharmacy (AMCP) Annual Meeting, March 31 - April 3, 2025; Houston, Texas

Barriers to Timely On-Demand Treatment of Hereditary Angioedema Attacks in Italian Patients

Andrea Zanichelli, Paola Triggianese, Pietro Accardo, Francesco Arcoleo, Donatella Bignardi, Caterina Colangelo, Francesco Giardino, Antonio Gidaro, Marica Giliberti, Maria Domenica Guarino, Paola Lucia Minciullo, Stefania Nicola, Francesca Perego, Riccardo Senter, Giuseppe Spadaro, Massimo Triggiani, Sherry Danese, Julie Ulloa, Vibha Desai, Paul Audhya, Mauro Cancian

Presented at Italian Network for Hereditary and Acquired Angioedema (ITACA) Meeting; March 27-29, 2025; Palermo, Italy

Efficacy and Safety of Sebetralstat for On-demand Treatment of Hereditary Angioedema in Pooled Analysis of Placebo-controlled Clinical Trials

Mauro Cancian, Jonathan Bernstein, Danny Cohn, Henriette Farkas, William Lumry, Marc Riedl, Andrea Zanichelli, James Hao, Michael Smith, Christopher Yea, Paul Audhya, Emel Aygören-Pürsün, Sorena Kiani-Alikhan

Presented at Italian Network for Hereditary and Acquired Angioedema (ITACA) Meeting; March 27-29, 2025; Palermo, Italy

Indirect Treatment Comparison of Oral Sebetralstat and Intravenous Recombinant Human C1 Esterase Inhibitor for On-demand Treatment of Hereditary Angioedema Attacks

H. Henry Li, Emel Aygören-Pürsün, Markus Magerl, Timothy Craig, Michael Manning, Noemi Hummel, Agnieszka Kopiec, Shuai Fu, James Morris, Alice Wang, Paul Audhya, Jonathan Bernstein

Allergy Asthma Clin Immunol. 2025 Mar 15;21(1):10

Barriers to Timely On-Demand Treatment of Hereditary Angioedema Attacks in Italian Patients

Mauro Cancian, Paola Triggianese, Pietro Accardo, Francesco Arcoleo, Donatella Bignardi, Caterina Colangelo, Francesco Giardino, Antonio Gidaro, Marica Giliberti, Maria Domenica Guarino, Paola Lucia Minciullo, Stefania Nicola, Francesca Perego, Riccardo Senter, Giuseppe Spadaro, Massimo Triggiani, Sherry Danese, Julie Ulloa, Vibha Desai, Paul Audhya, Andrea Zanichelli

Presented at American Academy of Allergy, Asthma, and Immunology/World Allergy Organization (AAAAI/WAO) Joint Conference; February 28-March 3, 2025; San Diego, California

Burden of Injectable On-Demand Treatment for Hereditary Angioedema Attacks in Adolescents

Mauro Cancian, Paula Busse, Tariq El-Shanawany, Maeve O’Connor, Sinisa Savic, Paola Triggianese, Patrick Yong, Andrea Zanichelli, Sherry Danese, Julie Ulloa, Vibha Desai, Paul Audhya, Sandra Christiansen

Presented at American Academy of Allergy, Asthma, and Immunology/World Allergy Organization (AAAAI/WAO) Joint Conference; February 28-March 3, 2025; San Diego, California

Delays in the On-Demand Treatment of Hereditary Angioedema Attacks and Associated Barriers Reported in Different Healthcare Systems

Patrick Yong, Paula Busse, Timothy Craig, Tariq El-Shanawany, Padmalal Gurugama, Rashmi Jain, Maeve O’Connor, Cristine Radojicic, Sinisa Savic, H James Wedner, Sherry Danese, Julie Ulloa, Vibha Desai, Paul Audhya, Sandra Christiansen

Presented at American Academy of Allergy, Asthma, and Immunology/World Allergy Organization (AAAAI/WAO) Joint Conference; February 28-March 3, 2025; San Diego, California

Effectiveness of Sebetralstat for the On-demand Treatment of Laryngeal Hereditary Angioedema Attacks: Interim Analysis from KONFIDENT-S

Jonathan Bernstein, Emel Aygören-Pürsün, Vesna Grivcheva-Panovska, Inmaculada Martinez-Saguer, Danny Cohn, William Lumry, Marc Riedl, Andrea Zanichelli, James Hao, Michael Smith, Christopher Yea, Paul Audhya, Henriette Farkas

Presented at American Academy of Allergy, Asthma, and Immunology/World Allergy Organization (AAAAI/WAO) Joint Conference; February 28-March 3, 2025; San Diego, California

On-demand Treatment Of Hereditary Angioedema Attacks With Sebetralstat In Adolescents: Pooled Analysis From KONFIDENT And KONFIDENT-S

Danny Cohn, Aharon Kessel, Tamar Kinaciyan, Rand Arnaout, Jonathan Peter, H James Wedner, Emel Aygören-Pürsün, Jonathan Bernstein, Henriette Farkas, William Lumry, Marcus Maurer, Marc Riedl, Andrea Zanichelli, James Hao, Matthew Iverson, Michael Smith, Christopher Yea, Paul Audhya, Fotios Psarros

Presented at American Academy of Allergy, Asthma, and Immunology/World Allergy Organization (AAAAI/WAO) Joint Conference; February 28-March 3, 2025; San Diego, California

Study to Adjudicate Hereditary Angioedema with Normal C1INH Diagnoses in the PIONEER-HAE Database

Maeve O’Connor, Dana Withrow, Scott Milligan, Vibha Desai, Paul Audhya, Marc Riedl

Presented at American Academy of Allergy, Asthma, and Immunology/World Allergy Organization (AAAAI/WAO) Joint Conference; February 28-March 3, 2025; San Diego, California

Impact of Long-Term Prophylaxis Adherence in Hereditary Angioedema Patients: Results of a Claims Database Analysis

Raffi Tachdjian, Daniel Soteres, Maeve O'Connor, Chirag Maheshwari, Alice Wang, Paul Audhya, Timothy Craig

Presented at the Western Society of Allergy, Asthma & Immunology (WSAAI) Annual Meeting; February 9-13, 2025; Waimea, Hawaii

Safety and Effectiveness of Sebetralstat in Patients with Hereditary Angioedema Receiving Long-term Prophylaxis: Interim Analysis from the KONFIDENT-S Open-label Study

Marc Riedl, Jonathan Bernstein, H Henry Li, Michael Manning, Jason Raasch, James Hao, Michael Smith, Paul Audhya, William Lumry

Presented at the Western Society of Allergy, Asthma & Immunology (WSAAI) Annual Meeting; February 9-13, 2025; Waimea, Hawaii

Sebetralstat for Treatment of Hereditary Angioedema Attacks in Patients Receiving Berotralstat: Interim Analysis from the KONFIDENT-S Open-label Study

Michael Manning, Marc Riedl, Raffi Tachdijan, H Henry Li, H James Wedner, Daniel Soteres, James Hao, Michael Smith, Paul Audhya, Tamar Kinaciyan

Presented at the Western Society of Allergy, Asthma & Immunology (WSAAI) Annual Meeting; February 9-13, 2025; Waimea, Hawaii

Management of Hereditary Angioedema Attacks by Patients on Long-term Prophylaxis Versus On-demand Therapy Only

William Lumry, Anete Grumach, Stephen Betschel, Cristine Radojicic, Sally van Kooten, Markus Heckmann, Sherry Danese, Neil Malloy, Ledia Goga, Mar Guilarte

Allergy Asthma Proc. 2025 Jan 1;46(1):32-37.

Efficacy and Safety of Sebetralstat for On-demand Treatment of Hereditary Angioedema in Pooled Analysis of Placebo-controlled Clinical Trials

Patrick Yong, Jonathan Bernstein, Danny Cohn, Henriette Farkas, William Lumry, Marc Riedl, Andrea Zanichelli, James Hao, Michael Smith, Christopher Yea, Paul Audhya, Emel Aygören-Pürsün, Sinisa Savic, Sorena Kiani-Alikhan

Presented at British Society for Immunology Clinical Immunology Professional Network (BSI-CIPN) Conference; December 9-10, 2024; Birmingham, United Kingdom

Impact of Delayed Treatment of Hereditary Angioedema Attacks on Quality of Life and Ability to Work

Patrick Yong, Rashmi Jain, Tomaz Garcez, Sorena Kiani-Alikhan, Vibha Desai, Tomas Andriotti, Paul Audhya, Sherry Danese, Julie Ulloa, Tariq El-Shanawany, Padmalal Gurugama, Sinisa Savic

Presented at British Society for Immunology Clinical Immunology Professional Network (BSI-CIPN) Conference; December 9-10, 2024; Birmingham, United Kingdom

Impact of Hereditary Angioedema Attacks on Quality of Life and Ability to Work Among UK Patients Receiving Long-term Prophylaxis or On-demand Only

Sinisa Savic, Tariq El-Shanawany, Padmalal Gurugama, Rashmi Jain, Vibha Desai, Tomas Andriotti, Paul Audhya, Sherry Danese, Julie Ulloa, Tomaz Garcez, Sorena Kiani-Alikhan, Patrick Yong

Presented at British Society for Immunology Clinical Immunology Professional Network (BSI-CIPN) Conference; December 9-10, 2024; Birmingham, United Kingdom

Hereditary Angioedema Attacks in Patients Receiving Long‑Term Prophylaxis: A Systematic Review

Hilary Longhurst, Mauro Cancian, Vesna Grivcheva‑Panovska, Majed Koleilat, Markus Magerl, Sinisa Savic, Marcin Stobiecki, Raffi Tachdjian, Bridget Healy, Christopher Yea, Paul Audhya, Laurence Bouillet

Clin Rev Allergy Immunol. 2024 Dec;67(1-3):83-95.

Correlation of Time to Treatment with Attack Duration in the Sebetralstat KONFIDENT Phase 3 Trial

Timothy Craig, Jonathan Bernstein, Hilary Longhurst, James Hao, Michael Smith, Paul Audhya, Christopher Yea, Marcus Maurer

Presented at American College of Allergy, Asthma, and Immunology (ACAAI) Conference; October 24-28, 2024; Boston, Massachusetts

Indirect Treatment Comparison of Oral Sebetralstat and Intravenous rhC1-INH as On-demand Treatments for Hereditary Angioedema

H Henry Li, Markus Magerl, Timothy Craig, Michael Manning, Noemi Hummel, Alice Wang, Paul Audhya, Jonathan Bernstein

Presented at American College of Allergy, Asthma, and Immunology (ACAAI) Conference; October 24-28, 2024; Boston, Massachusetts

On-demand Treatment of Laryngeal Hereditary Angioedema Attacks with Sebetralstat: Pooled Analysis from KONFIDENT and KONFIDENT-S

Emel Aygören-Pürsün, Jonathan Bernstein, William Lumry, Paul Audhya, James Hao, Michael Smith, Christopher Yea, Marc Riedl

Presented at American College of Allergy, Asthma, and Immunology (ACAAI) Conference; October 24-28, 2024; Boston, MA

Patient-Reported Anxiety Impacts Utilization of Injectable On-demand Treatment of Hereditary Angioedema Attacks

Cristine Radojicic, Autumn Burnette, Sally van Kooten, Neil Malloy, Markus Heckmann, Hilary Longhurst

Presented at American College of Allergy, Asthma, and Immunology (ACAAI) Conference; October 24-28, 2024; Boston, Massachusetts

Substantial Reduction of Hereditary Angioedema Attack Symptom Burden in the Sebetralstat Phase 3 KONFIDENT Trial

William Lumry, Danny Cohn, Jonathan Bernstein, Paul Audhya, James Hao, Michael Smith, Christopher Yea, Marc Riedl

Presented at American College of Allergy, Asthma, and Immunology (ACAAI) Conference; October 24-28, 2024; Boston, Massachusetts

Real World Barriers to On-Demand Treatment for Attacks in Hereditary Angioedema: A Patient Survey

Daisuke Honda, Sandra Christiansen, Julie Ulloa, Sherry Danese, Vibha Desai, Tomas Andriotti, Shigeru Yoshida, Paul Audhya, Michihiro Hide

Presented at the Japanese Society of Allergology Congress; October 18-20, 2024; Kyoto, Japan

Anxiety Associated with Parenteral On-Demand Treatment for Hereditary Angioedema Attacks

Andrea Zanichelli, Pietro Accardo, Francesco Arcoleo, Donatella Bignardi, Caterina Colangelo, Francesco Giardino, Antonio Gidaro, Marica Giliberti, Maria Domenica Guarino, Paola Lucia Minciullo, Stefania Nicola, Francesca Perego, Riccardo Senter, Giuseppe Spadaro, Paola Triggianese, Massimo Triggiani, Sherry Danese, Julie Ulloa, Vibha Desai, Tomas Andriotti, Paul Audhya, Mauro Cancian

Presented at the ACARE Global Angioedema Forum 2024; October 4-5, 2024; Copenhagen, Denmark

Global Frequency and Diagnosis of Hereditary Angioedema with Normal C1INH: A Real World ACARE Survey

Markus Magerl, Marc Riedl, Sherry Danese, Julie Ulloa, Paul Audhya, Marcus Maurer

Presented at the ACARE Global Angioedema Forum 2024; October 4-5, 2024; Copenhagen, Denmark

Impact of Oral Sebetralstat on Hereditary Angioedema Attack-associated Anxiety: Analysis From the Phase 3 KONFIDENT Trial

Marcus Maurer, Danny Cohn, Jonathan Bernstein, Henriette Farkas, William Lumry, Marc Riedl, Andrea Zanichelli, James Hao, Michael Smith, Paul Audhya, Christopher Yea, Emel Aygören-Pürsün

Presented at the ACARE Global Angioedema Forum 2024; October 4-5, 2024; Copenhagen, Denmark

KONFIDENT Trial of Oral Sebetralstat for Treatment of Hereditary Angioedema Attacks: Analysis of the European and US Patient Populations

Andrea Zanichelli, Emel Aygören-Pürsün, Jonathan Bernstein, Henriette Farkas, William Lumry, Marcus Maurer, Marc Riedl, James Hao, Michael Smith, Paul Audhya, Christopher Yea, Danny Cohn

Presented at the ACARE Global Angioedema Forum 2024; October 4-5, 2024; Copenhagen, Denmark

Delayed On-demand Treatment of Hereditary Angioedema Attacks: Italian Patient Perceptions and Associated Barriers

Stefania Nicola, Riccardo Senter, Pietro Accardo, Francesco Arcoleo, Donatella Bignardi, Caterina Colangelo, Francesco Giardino, Antonio Gidaro, Marica Giliberti, Maria Domenica Guarino, Paola Lucia Minciullo, Francesca Perego, Giuseppe Spadaro, Paola Triggianese, Massimo Triggiani, Sherry Danese, Julie Ulloa, Vibha Desai, Tomas Andriotti, Paul Audhya, Andrea Zanichelli, Mauro Cancian

Presented at the 2024 National Congress of the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC); October 4-5, 2024; Rome, Italy

Advent of Oral Medications for the Treatment of Hereditary Angioedema

Anna Valerieva, Teresa Caballero, Markus Magerl, Joao Frade, Paul Audhya, Timothy Craig

Clin Transl Allergy. 2024 Sep;14(9):e12391

A Specific, Sensitivity Assay Measuring Patient Sample Plasma Kallikrein Activity

Daniel Lee, Arije Ghannam, Nivetha Murugesan, Denis Vincent, Adrian Mogg, Michael Smith, Sally Hampton, Edward Feener

Presented at Bradykinin Symposium; September 4-6, 2024; Berlin, Germany

Delayed On-demand Treatment of Hereditary Angioedema Attacks and Associated Barriers Reported by Italian Patients

Mauro Cancian, Pietro Accardo, Francesco Arcoleo, Donatella Bignardi, Caterina Colangelo, Francesco Giardino, Antonio Gidaro, Marica Giliberti, Maria Domenica Guarino, Paola Lucia Minciullo, Stefania Nicola, Francesca Perego, Riccardo Senter, Giuseppe Spadaro, Paola Triggianese, Massimo Triggiani, Sherry Danese, Julie Ulloa, Vibha Desai, Tomas Andriotti, Paul Audhya, Andrea Zanichelli

Presented at Bradykinin Symposium; September 4-6, 2024; Berlin, Germany

KONFIDENT-S Interim Analysis: Sebetralstat for Hereditary Angioedema Attacks Including Laryngeal

Henriette Farkas, Marc Riedl, Emel Aygören-Pürsün, William Lumry, Andrea Zanichelli, James Hao, Matthew Iverson, Michael Smith, Christopher Yea, Paul Audhya, Jonathan Bernstein, Marcus Maurer, Danny Cohn

Presented at Bradykinin Symposium; September 4-6, 2024; Berlin, Germany

Pooled Sebetralstat Placebo-controlled Efficacy for On-demand Treatment of Hereditary Angioedema

Marcus Maurer, Jonathan Bernstein, Danny Cohn, Henriette Farkas, William Lumry, Marc Riedl, Andrea Zanichelli, James Hao, Matthew Iverson, Michael Smith, Christopher Yea, Paul Audhya, Sorena Kiani-Alikhan, Emel Aygören-Pürsün

Presented at Bradykinin Symposium; September 4-6, 2024; Berlin, Germany

Pooled Sebetralstat Placebo-controlled Safety for On-demand Treatment of Hereditary Angioedema

Emel Aygören-Pürsün, Jonathan Bernstein, Danny Cohn, Henriette Farkas, William Lumry, Marc Riedl, Andrea Zanichelli, Samuel Owiredu-Yeboa, James Hao, Michael Smith, Christopher Yea, Paul Audhya, Sorena Kiani-Alikhan, Marcus Maurer

Presented at Bradykinin Symposium; September 4-6, 2024; Berlin, Germany

Closing Gaps in Hereditary Angioedema Management: Addressing Delays in On-demand Treatment

Douglas Jones

EMJ Allergy Immunol. 2024 Jul;9(1):37-43

Oral Sebetralstat for On-demand Treatment of Hereditary Angioedema Attacks

Marc Riedl, Henriette Farkas, Emel Aygören-Pürsün, Fotis Psarros, Daniel Soteres, Maria Staevska, Mauro Cancian, David Hagin, Daisuke Honda, Isaac Melamed, Sinisa Savic, Marcin Stobiecki, Paula Busse, Eunice Dias de Castro, Nancy Agmon-Levin, Richard Gower, Aharon Kessel, Marcin Kurowski, Ramon Lleonart, Vesna Grivcheva-Panovska, James Wedner, Paul Audhya, James Hao, Matthew Iverson, Michael Smith, Christopher Yea, William Lumry, Andrea Zanichelli, Jonathan Bernstein, Marcus Maurer, and Danny Cohn for the KONFIDENT Investigators

N Engl J Med. 2024 Jul 4;391(1):32-43

The Complexities of Decision-Making Associated with On-Demand Treatment of Hereditary Angioedema (HAE) Attacks

Stephen Betschel, Teresa Caballero, Douglas Jones, Hilary Longhurst, Michael Manning, Sally van Kooten, Markus Heckmann, Sherry Danese, Ledia Goga, Autumn Burnette

Allergy Asthma Clin Immunol. 2024 Jul 25;20(1):43

Anxiety Associated with On-demand Treatment of Hereditary Angioedema (HAE) Attacks

Patrick Yong, Tariq El-Shanawany, Padmalal Gurugama, Rashmi Jain, Sherry Danese, Julie Ulloa, Vibha Desai, Paul Audhya, Sinisa Savic